로고

  • HOME
  • SITEMAP
  • kOREAN
Home > SmartFilm®Technology > ODF

Orally Disintegrating Film (ODF) is an improved dosage form which is easy to take on tongue without water and has
better patients’ compliance, and more upgraded than Orally Disintegrating Tablet (ODT) which takes the same way.

ODF is a thin film that is similar in shape and thickness to stamp and is good to place on tongue.
ODF disintegrates rapidly when placed on or under the tongue, the oral cavity and then absorbed through the
gastrointestinal tract. When it is disintegrated under the tongue, it directly delivers drug to blood stream. ODF is a
process of development to satisfy the need of patients in a rapidly changing of life style. It has many differentiated
advantages compared to other formulations such as tablet, capsule, syrup so that the development and substitution
of drug dosage forms that requires changing to the dosage form will be continuing steadily.

ODF started from consumer product, health functional food, Non-Rx is now selling on market in mouthwashes, cold
medicines, digestive medicines, and will be expanded to Rx areas for commercialization by development and sale.
As drug delivery system like ODF substitutes the traditional dosage forms, it will be further expanded and developed
into medical devices, diagnostic reagents, and Non-Rx.

It is hard for infants, elderly patients, disabled people, and intensive-care patients and patients with eating disorder
or dysphasia to swallow conventional tablet or capsules easily. These people account to 25% of total populations.
It was also reported that half of the respondents answered are afraid of swallowing hard tablets or capsules.
On the other hand, ODF can be taken without water and dissolve in mouth quickly so it can reduce the difficulties of
swallowing drug.

Liquid preparations such as syrup and suspension are commonly used for children but in medication process,
under-dosing than usual dose or overdosing by giving drug repeatedly after vomiting is commonly occurring problems.
In case of elderly patients, dysphasia patient and patients with cerebral nerve disorders, it is difficult to take drugs
themselves and almost impossible to confirm whether they take the accurate dosage. These patients require proper
dosage forms to administer accurate dose. Drugs with narrow therapeutic window or drugs that are afraid of inducing
tolerance should be administered with pharmacologically accurate dosage.

ODF can improve safety and efficacy of the drug because ODF can be administered with accurate dosage compared to conventional oral dosage forms. Recently, FDA emphasized not only the safety of the drug, but also the accurate
dosage for infants.

ODT is easily breakable so it has difficulties in storage and portability. But ODF is in unit package, easy to carry or
store, so people can carry enough packages for long-distance travel.

All of oral dosages such as tablets have disadvantages to be affected by gastric fluids, bile acids or other digestive
enzymes before entering the systemic circulation so that more drugs are needed and the onset of drug effect may be
generally delayed. On the other hand, ODF can directly deliver drug through oral mucosa without the first pass effect
so that ODT can show faster drug effect with relatively lower dosage by improving bioavailability.

According to the above advantages of ODF, conventional tablets, capsules or liquid syrups marketed for infants,
elderly patients, and patients with cerebral nerve disorders and preparation for erectile dysfunction are making
progress to replace with ODF. Under the current circumstances with intensified competition of generics, ODF drug
delivery system can have a chance to enhance Going Concern Value and profit levels for pharmaceutical companies.